DNA damage induced neuroinflammation in neurodegenerative disease
نویسندگان
چکیده
منابع مشابه
[Microglia in neurodegenerative disorders and neuroinflammation].
Microglia often accumulate around degenerating neurons. These macrophage-like immune cells produce a variety of neurotoxic and neuroprotective factors. Thus, the accumulation of glia in various neurologic disorders does not reflect only gliosis, but likely results in an active contribution to neuroinflammation, neural degeneration, and cell regeneration. We previously showed that glutamate is t...
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Neurodegeneration is a phenomenon that occurs in the central nervous system through the hallmarks associating the loss of neuronal structure and function. Neurodegeneration is observed after viral insult and mostly in various so-called 'neurodegenerative diseases', generally observed in the elderly, such as Alzheimer's disease, multiple sclerosis, Parkinson's disease and amyotrophic lateral scl...
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The goal of this project is to see if and how uranium (U) may contribute to DNA damage. Radioactive forms of uranium have been used as fuel for nuclear reactors and as fissionable material for atomic weapons, tank armor, and ammunition shells. People who work with or live near processed uranium have experienced higher incidence of lung cancer, which has been attributed to radon, a radioactive d...
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ژورنال
عنوان ژورنال: Alzheimer's & Dementia
سال: 2020
ISSN: 1552-5260,1552-5279
DOI: 10.1002/alz.047445